Resveratrol is thought to act as a caloric restriction mimetic, which activates beneficial cellular pathways. When David published his book Lifespan in 2019 he was only taking resveratrol with his yogurt in the morning. Yes, David Sinclair is legit. Here the list and dosage of anti-aging supplements that David Sinclair takes (from the Joe Rogan podcast): He has been taking resveratrol for 12 years while NMN and metformin for about 3. Dr. David Sinclair has formulated a capsule version of a precursor to NAD+ called Nicotinamide mononucleotide (NMN). Examples of generally reputable brands include: Whilst David generally tries to get all the vitamins and minerals he needs from his diet, he does still take some vitamins daily. Whilst vitamin K1 is prioritized for use in the liver, vitamin K2 appears to be prioritized for use in the periphery, which will support calcium transport24The relationship between vitamin K and peripheral arterial disease Vissers et al. This is viable for David who exercises vigorously in the order of 1-2x per week, but for someone training often, this might be impractical. Its worth noting the study used NR, not NMN. Dr. David Sinclair obtained his doctoral degree in molecular genetics at the University of New South Wales, Sydney, in 1995. David Sinclair Supplements Regimen: Mornings NMN - 1 gram daily - mornings - in pill form swallowed with water Resveratrol - 1 gram daily - mornings - with yogurt Fisetin - 500mg daily - mornings - with yogurt One group took it for 6 weeks (n=21) and another for 12 weeks (n=10). Resveratrol is a molecule thats found (in small amounts) in the skin of foods like grapes, blueberries, raspberries, mulberries, and peanuts. As Dr Brenner points out below, monitoring homocysteine levels (via blood test) is a proxy for methylation issues. This emulates the method David uses to take his NMN; in capsules swallowed with a glass of water. But he argues that if he does Both have senolytic and SIRT1 activating properties. In common with metformin, it has the ability to: Berberine dosage in treating diabetes is not entirely dissimilar to Metformin. No specific details are available at the moment. Dr. David Sinclair is a firm believer in restricting caloric intake to extend life expectancy. Molecules that are discovered today will need years of testing before they can even come close to rival the amount of data and patient years accumulated by metformin. Whilst David doesnt mention in the book what brand he uses, or how much he takes, he mentions in the podcast with Dave Asprey (link) that he takes at least 2,000iu per day. Examples of alpha lipoic acid brands are: Also in the podcast with Dave Asprey (link), David says that he takes Coenzyme Q10 because hes taking a statin. Alcohol is a major carcinogen, says Dr. Sinclair, who believes that if you drink alcohol, you should limit yourself to one glass of wine per day. That would mean over $100 trillion in health-care savings, according to Harvard biologist David Sinclair. I dont know if a study has compared NR to NMN to see, gram for gram, which raises NAD levels more in humans. Rhonda Patrick's General Eating Guidelines Rhonda Patrick's Breakfast Breakfast 1 Eggs Tomatillo Salsa Avocado Oil Mustard Powder Kale Grapefruit Breakfast 2 Cereal Blueberries Pomegranate Flaxseed Coconut Milk Raw Cacao Nibs Hydrolized Collagen Powder Almond Butter Yogurt or VSL #3 Rhonda Patrick on Coffee and Intermittent Fasting ), which can be a bit confusing, so Ill try to summarize them: Its perhaps worth noting, if you heard David on Joe Rogan in June 2021 (link), he mentioned working on a product to track the epigenetic clock (based on the work of Steve Horvath). In a tweet thread by their chief scientific adviser Charles Brenner, he explains that Chromadex took the potential risk of NR depleting methyl groups seriously. Robb Wolfs Food Matrix Paleo Meal Generator, How to Eat More for Hardgainers (using The Hungry Brain). 500mg of fisetin dailly in the morning with yogurt. The core yogurt making process is combining yogurt bacteria with milk, and keeping the liquid at around 115F for 5-10 hours (often overnight). David Andrew Sinclair (born 1969 in Australia) is a biologist and professor of genetics. There has been some discussion and concern that by increasing the amount of methylation the body needs to do (through supplementation of NR/NMN), we might deplete the body of methyl groups needed to carry out essential processes. He has probably received 0 hours of nutritional education, but also does not claim to be even remotely an expert on nutrition. To which David suggests, at the least, it probably wasnt causing Denham any harm. Many prescription drugs are toxic and dangerous, says Dr. Sinclair, who believes that supplements can also play an important role in preventing damage from free radicals and promoting health. People think that cigarettes are safe-cigarettes kill half a million Americans every year, says Dr. Sinclair, who believes the health consequences from smoking are so severe that many people have been driven to drug abuse. David is a Ph.D., A.O. 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