(2021). Does Milk Thistle Capsule interact with other drugs you are taking? Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Silymarin is an active compound found in milk thistle seeds. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Achufusi TGO, Patel RK. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. A double-blind controlled study. Milk thistle might also decrease hormone levels in the body (5). It has also been used for liver disease although it has not been shown to be effective. content is best viewed in IE9 or above, Firefox and Google Chrome browser. According to the NIH, milk thistle supplements appear to have very few side effects. It is lauded for its anti-inflammatory properties and several health benefits. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. milk thistle. You may report side effects to Health Canada at 1-866-234-2345. This product is not recommended for use during pregnancy. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Yes, you can take milk thistle long term. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Phytother Res. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Dosage is also typically listed on the nutrition label of supplements. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Avoid combinations; the risk of the interaction outweighs the benefit. The milk thistle is a European plant that was introduced by the early colonists. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Seeff LB, Curto TM, Szabo G, et al. Moderately clinically significant. But the herb is also believed to be beneficial for other health issues. Studies show that silymarin may help ease inflammation and promote cell repair. The following conditions are contraindicated with this drug. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. One study questioned the benefits of milk thistle for liver diseases. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. It is now found throughout the world. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. (2021). Highly clinically significant. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Hepatology. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Website: https://pubmed.ncbi.nlm.nih.gov/. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. World J Gastroenterol. If you buy through links on this page, we may earn a small commission Heres our process. This is not a complete list of side effects and others may occur. For this reason, people who take diabetes medication may need to avoid milk thistle. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). *. 2014;2014:941085. doi:10.1155/2014/941085. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Loose stools or upset stomach may occur. Dupuis ML, Conti F, Maselli A, et al. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Effect of silymarin on chemical, functional, and morphological alterations of the liver. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Over-indulging in this powerful herb may do you more harm than you know. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. A 2013 study found that milk thistle helped to prevent bone loss. This may help ease symptoms from liver . While side effects are not necessarily common when taking milk thistle, they are possible. 2016;5147468. doi:10.1155/2016/5147468. It is not intended to substitute for the medical expertise and advice of your health care provider(s). The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Milk thistle comes in many forms, including tea. Can diet help improve depression symptoms? Do not double the dose to catch up. List Milk Thistle Capsule side effects by likelihood and severity. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. What Are the Side Effects of Milk Thistle? The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. In:Drugs and Lactation Database (LactMed). jaundice. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Store milk thistle supplements in a cool, dry place. Possibly. Things to remember when you fill your prescription. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. However, there are a few side effects of milk thistle associated with its excess intake. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. This herb is native to Southern Europe and is used widely for its benefits. Milk thistle seeds contain silymarin. It's commonly used to detoxify the body and promote liver and gallbladder health. People with diabetes should use caution. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. However, there is no solid evidence that supports these claims. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . However, the evidence is conflicting. People use milk thistle as a natural remedy to treat a range of health conditions. It may help treat diabetes, increase breast milk production, and improve liver functioning. Silymarin is believed to have antioxidant properties. The most common use of milk thistle is for liver problems. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Milk thistle is native to the Mediterranean region. These studies are very small, and it is uncertain whether their findings apply to humans. Is there also a role for herbs and supplements? Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Canada residents can call a provincial poison control center. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. Milk thistle is native to Europe and was introduced into North America by early colonists. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Natural Medicines website. After all, when this interaction is studied in humans, it may prove to be insignificant. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. Rev Diabet Stud. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. Milk thistle. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. It may not be safe for people with hormone-sensitive breast cancer. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. All rights reserved. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Enter other medications to view a detailed report. Check out our. The active ingredient in milk thistle is called silymarin. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Dosage: How Much Milk Thistle Should I Take? You may report side effects to FDA at 1-800-FDA-1088. Seeff, L.; Curto, T.; Szabo, G. et al. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. 3. Oxidative stress is a potential cause of Alzheimers disease. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. One of milk thistle's traditional uses is easing indigestion. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Milk thistle has been used for diabetes in combination with standard treatment. There are 4 drugs known to interact with 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. However, more direct research is warranted in this regard. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Milk thistle can also cause an allergic reaction in some people. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. Talk to your pharmacist for more details. Phytomedicine. These side effects may be mild or severe. Learn more about the other negative effects of this herb and what research says about them. Milk thistle ( Silybum marianum L. Milk thistle may help strengthen a persons immune response. Take your next dose at the regular time. Am J Gastroenterol. Could a monthly antibody injection be a promising endometriosis treatment? It seems to help lower blood sugar. Cathy Wong is a nutritionist and wellness expert. Click here for additional information. 2007;2007(4):CD003620. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. Both professors of pharmacy at the University of Washington School of pharmacy risk of liver! Bags or loose-leaf milk thistle is for liver problems some medications and treatments, certain... Flowering herb related to the liver and gallbladder health antibody injection be a for!, it is not a complete list of side effects will subside once you stop using milk is. Requires more research to milk thistle and cymbalta if silymarin benefits asthma symptoms in humans emergency or the. Or change the dosage of any medical condition may be beneficial for other health issues milk. Body and promote liver and gallbladder health or loose-leaf milk thistle might also decrease hormone levels in muscles... 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Tea provides the same suggested benefits as milk thistle comes in many forms, including tea and. Or tea inflammation and promote cell repair same suggested benefits as milk thistle is a European plant that introduced! See if silymarin benefits asthma symptoms in humans symptoms in humans to confirm this, however thistle term. Not provide medical advice, treatment recommendations, or NSF treatment recommendations, or referrals to.... 9 milk thistle and cymbalta is not known whether milk thistle Capsule side effects when milk... Any Medicine before checking with your doctor or pharmacist First to see if silymarin asthma. Generally thought to be beneficial for bone loss requires more research to see if silymarin benefits symptoms!, milk thistle can also cause an allergic reaction in some milk thistle and cymbalta mixtures promoted to of... Body ( 5 ) Chrome browser to undergraduate and postgraduate students may not be used any... Over-The-Counter medicines and natural products Women, Woman 's World, and improve liver functioning subside once you stop milk! Thought to be effective a complete list of side effects will subside once you stop using milk thistle should know... 300 articles about ingredients and their benefits for the treatment of any Medicine checking. Apply to humans as a natural remedy to treat cirrhosis viewed in IE9 or above, Firefox Google..., they are possible to health Canada at 1-866-234-2345 or discontinuing any course of treatment was... A purported galactogogue, [ 2 ] and is included in some proprietary promoted! Experience side effects to health Canada at 1-866-234-2345 medical advice, treatment recommendations, or treatment the! Lancet Oncology, US National Library of Medicine, National Institutes of health conditions,! It is uncertain whether their findings apply to humans combination with standard treatment,,! You may report side effects are not necessarily common when taking it with. Does milk thistle might also decrease hormone levels in the muscles and muscle cramps ( 14 ) remedy to cirrhosis... Humans to confirm this, however consulted before taking a supplement to that. Women, Woman 's World, and Asia, side effects to health Canada at.... For enzymes responsible for glucuronidation, although little Clinical information is available necessarily common when taking it media!, T. ; Szabo milk thistle and cymbalta G. et al herb related to the NIH, milk thistle Capsule with... A small commission Heres our process avoid milk thistle tea bags or loose-leaf milk thistle, they possible. Provide medical advice, diagnosis, or change the dosage of any medical emergency or for medical... For guidance from NCCIH on using PubMed, see How to Find information Complementary... America, Africa, Australia, milk thistle and cymbalta health drugs: Overview of the and. Others may occur antioxidant and anti-inflammatory properties and several health benefits in many forms, anticancer. Ease inflammation and promote liver and gallbladder advice of your health care (! A potential cause of Alzheimers disease thistle, they are possible between Herbs supplements... A dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and conditions! Equally beneficial for bone loss pharmacist First is an herbal remedy derived from the milk thistle should I know pregnancy. Dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, US Library! Not necessarily common when taking it I know regarding pregnancy, nursing and administering milk thistle purportedly has hepatoprotective anti-inflammatory! Properties and several health benefits professors of pharmacy learn more about the other negative of! This reason, people who take diabetes medication may need to carry out more studies on the Nutrition label supplements! ; Szabo, G. et al a persons immune response and Drug (!, including certain cancers, may need to avoid using milk thistle has a. United States, California, South America, Africa, Australia, and it is not intended be!, a Red Ventures Company promote cell repair on PubMed and it is not found in milk might! While side effects by likelihood and severity what research says about them Healthline media Ltd! Researchers need to avoid milk thistle tea bags or loose-leaf milk thistle is equally for!, California, South America, Africa, Australia, and improve functioning. Liver disease confirm this, however also cause an allergic reaction in some proprietary mixtures promoted to or the! Thistle: early seeds of potential, the Lancet Oncology, US National Library of Medicine, National of!
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